Sentence examples for underpinning bone from inspiring English sources

As such, there is less evidence to substantiate any theories underpinning bone changes in primary OA.

In this study we have utilised oligonucleotide microarrays to determine the transcriptomic response of human osteoblasts and further describe the molecular mechanisms underpinning steroid associated bone density loss.

The mechanisms underpinning the mobilisation of bone mineral during lactation and its later restoration are not fully understood.

The continual follow-up of the ALSPAC cohort, and cohorts similar to this, will facilitate the detection of genetic variants associated with the rate of BMD acquisition, which will aid in our understanding of the biological pathways underpinning attainment of peak bone mass.

However, the molecular and cellular mechanisms underpinning these HIV associated changes in bone biology remain unclear, with some, but by no means all, studies linking these abnormalities with the use of potent antiretroviral medications [ 3- 11].

The molecular mechanisms underpinning such inflow of mesenchymal cells from bone marrow into synovium during inflammatory synovitis are not fully known but chemokines would likely play a role [ 33].

We have focused on establishing the significance of the cell surface hyaluronan receptor CD44 in underpinning the preferential metastasis of breast cancer cells to bone.

Pulmonary arterial hypertension (PAH) occurs more frequently in women with mutations in bone morphogenetic protein receptor type 2 (BMPR2) and dysfunctional BMPR2 signalling underpinning heritable PAH.

Despite the numerous pathophysiological alterations detected in subchondral bone with OA, we still lack a clear understanding of the mechanisms underpinning these phenomena and how these different aspects are interrelated to each other.

This paper reclaims the term "mechanotherapy" and presents the current scientific knowledge underpinning how load may be used therapeutically to stimulate tissue repair and remodelling in tendon, muscle, cartilage and bone.

underpinning his conviction.