The focus of these strategies has been type 2 diabetes, underpinned by the rationale that a slower rate of nutrient delivery to the small intestine would be desirable to compensate for the delay in insulin release and the resistance to its actions, which are characteristic of this disease.
This knowledge would help organisations to develop frameworks that are underpinned by an explicit rationale and which acknowledge any underlying assumptions, thus facilitating more informed and appropriate use.
These data show a clear rationale for combining HDIs with a range of chemotherapeutic agents, but that clinical trials must be underpinned by a clear mechanistic rationale specific to both experimental agents and tumour types.
"This transaction is underpinned by incredibly strong strategic rationale and is a win-win for all," said Marcus Anselm, partner at Clarity.
Careful selection of outcome measures underpinned by the focus and rationale for the intervention is imperative for accurate evaluation and to ensure that treatment effects are not missed.
We have demonstrated that it is feasible to develop interventions to change professional practice that are underpinned by a robust, scientific rationale.
Thus the final interventions are underpinned by a robust scientific rationale with which to explain "why and how" we expect each intervention to have their effect, and are placed within a sound theoretical framework that guides a process for their evaluation and refinement.
The approach presented in these partner papers promotes the development of professional behaviour change interventions that are replicable, are underpinned by a robust explanatory scientific rationale and that use generalisable elements of behaviour.
Its provisions are underpinned by the precautionary principle".
The post-war nationalisations were underpinned by an ideology of technocracy – the rationale being that State owned industry should be run by State employed experts.
The rationale for this is underpinned by the observations from PROWESS that approximately one-third of patients who had severe protein C deficiency at baseline were no longer severely deficient after 24 hours of DrotAA therapy, and that approximately one-quarter of patients who were not severely deficient at baseline were deficient at 24 hours, despite DrotAA treatment.
