Sentence examples for underpin the effects from inspiring English sources

Finally, we do not know if other, hitherto unknown mechanisms, may underpin the effects of vildagliptin in the heart.

The anti-metastatic mechanisms that may underpin the effects of low molecular weight heparins (LMWHs) in in vitro and preclinical melanoma models warrant translating to a clinical setting.

In order to provide further evidence that activation of NPR2, and consequent increases in cellular cGMP concentrations do not underpin the effects of CNP on RAoSMC and HUVEC, cGMP levels were measured in both cell types.

-wrap> In order to gain a better understanding of the molecular mechanisms that are likely to underpin the effects of the ΔN-Bcat mutation on intestinal tumor multiplicity, we monitored expression of the Wnt/β-catenin target genes myc and Ccnd1, which serve as a gatekeeper in Apc-dependent tumor formation (Sansom et al., 2007) and promote cell cycle progression, respectively.

The anti-metastatic mechanisms that may underpin the effects of heparin LMWH in in vitro and preclinical melanoma models warrant testing in the clinical setting as prevention or delay of brain metastases in melanoma appears to be a clinically relevant and measurable target.

We also showed that heightened physiological arousal is unlikely to underpin the effect: the presence of calming or energizing background music during the task did not differentially influence VSTM nor interact with emotional expression conditions, suggesting that enhanced VSTM for angry faces is valence-driven.

The mechanism underpinning the effects of Gsx on emotional reactivity probably involves altered gut brain endocrine signalling and also endocrine disturbances that are secondary to weight loss.

If the findings of the main RCT are clinically significant, the data obtained from each phase in the process of developing the intervention may add to the understanding of the mechanisms underpinning the effects of the intervention.

The amount of released F− ions was also measured with the aim of underpinning the effect of coatings and presence of fluorides species on the cell response.

At equilibrium, the theory is in agreement with data, and this agreement underpins the effect of chemical surface groups on electrode performance.

However, because this effect was not associated with a significant reduction in serum cholesterol levels, further studies are needed to better understand the mechanisms underpinning the effect of fenofibrate (17).