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This is recommended by the MRC as a means of safeguarding against problems of acceptability, compliance, delivery of the intervention, recruitment and retention, and smaller-than-expected effect sizes, which can undermine the evaluation of an intervention.
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"We are disappointed," he said, by the aspects of the decision "that undermine the rigor of the evaluation system".
Deviations from pure adherence to the intervention under evaluation undermine the value of ITT, and mean that patients may benefit from alternative methods of data presentation.
In January Mexico's states ratified a constitutional reform that paves the way for better training and stricter evaluation of teachers, which should undermine the power of the union.
In this year's filing, for example, the company said that imposing gender and minority requirements on the board selection process would be unduly restrictive and "would undermine the company's holistic evaluation of candidates".
"The harm from incorrect assumptions, such as those found in the cost-effectiveness evaluations of COX-2s, is that they undermine the efficient allocation of scarce health care resources," she added at the time.
From a research perspective, misclassification of individuals into diagnostic groups, for purposes of group comparison or for evaluation of novel treatment effects (e.g., Sachs et al. 2003), may bias or otherwise undermine the validity of research findings.
The second option would undermine the integrity of the House of Commons.
This could help to undermine the legitimacy of the insurgents.
The decision will further undermine the credibility of the poll.
But it will also undermine the object of the bill.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com