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There are many different dynamical mechanisms that can yield such patterns, and the particular correlations between the ISIs will depend on the underlying voltage dynamics (which, in our case, we assume to be given by Eq. (1)); in particular, it may be difficult to distinguish whether the dynamics are subthreshold or supra-threshold, since both can show similar ISI densities; see [22].
It is important to note that the scalp-recorded EEG represents the underlying voltage gradients, which may be altered as they pass through the volume conductor (i.e. body).
Future studies using E519C will enable a greater understanding of conformational changes underlying voltage sensor movements as well as dissection of the gating transitions that contribute to hERG channels' unique drug sensitivity and unusual current behavior.
The reason for this can be intuitively understood: a steep action potential enables the axon to respond fast to rapid membrane potential changes, whereas a less steep action potential onset will not be fast enough and, in the extreme case, it will "ignore" the underlying voltage modulations.
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A strong interplay between the voltage-sensor domain (VSD) and the pore domain (PD) underlies voltage-gated channel functions.
This mechanism has been assumed to underlie voltage-sensitive gating in Kv4 (Shal-type) channels as well, which generate rapidly activating and inactivating K+ current phenotypes designated "IA" in neurons and "Ito,fast" in cardiac myocytes [6] [8].
Transmission lines are occassionally tapped to provide intermediate connections to loads or reinforce the underlying lower voltage network through a transformer.
To inject the patterns of excitatory input we recorded in vivo, we added an AMPA synaptic conductance (Erev = 0 mV) which was varied dynamically to correspond to the conductance underlying our voltage clamp traces, assuming a driving force of 70 mV.
This led to the hypothesis that voltage-dependent movement of H+ through CLC-5 from the proton to gating glutamates underlies voltage-dependent gating (23); in many respects, this is harmonious with the proton-dependent gating of the CLC-0 Cl− channel (12).
Nevertheless, it has not yet been directly proven that flexoelectricity underlies the voltage-dependent responses in hair bundles and additional experiments will be necessary to test this hypothesis.
These results strengthen our conclusion that Slo3 underlies the voltage-, Cand-, alkaline-activatedated IKsper current in human sperm.
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CEO of Professional Science Editing for Scientists @ prosciediting.com