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This article considers the framework underlying validation and use of SEBs in specific chemoprevention models and methodologic issues in quantifying the effect of an agent.
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Subsequently, which knowledge gaps are chosen for experimental research is ultimately a human decision depending on research goals, biological novelty factors, ease of experimental validation, and underlying evidence of the knowledge gap's validity.
To do so, firms in hyper-competitive environments increasingly plan and design their products concurrent with the independent development and validation of underlying technologies.
The first two evaluations were designed to validate the features and functionality of AALFI and the underlying MAS before carrying out validation with potential stake holders.
Fig. 3 Performance of the different methods in the temporal split validation, grouped by underlying algorithm and colored by metric used.
Formal ontological mapping of all metadata terms ensured logical validation of the underlying concepts while enabling the addition of semantic relations.
Fig. 2 Performance of the different methods in the random split validation, grouped by underlying algorithm and colored by metric used.
Besides providing spatial predictions of soil water retention at the catchment scale, the study presents a detailed methodological insight to model setup and validation of the underlying machine learning approach with random forest.
Here, we investigate the technical reasons underlying reported failures in biomarker validation for non-small cell lung cancer (NSCLC).
Both of these previously reported studies (Peters et al. 2000; Vedal et al. 2004) focused on ICD therapeutic discharge without characterization or validation of the underlying arrhythmia.
This finding suggests persistence of the abnormalities in underlying processes and provides external validation for the diagnostic construct of AD-ADHD.
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