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Traditionally biomarkers are cell surface or intracellular molecular markers – here we suggest that the degree of leakiness of tumor blood vessels 'integrates' underlying tumor microenvironmental factors related to angiogenesis, and represents the underlying tumor pathomorphological status.
The reasons underlying tumor shrinkage remain unclear.
The mechanisms underlying tumor immune escape are still to be fully dissected.
Inflammatory cancer, however, has more marked skin enhancement, with underlying tumor enhancement in either a septal or solid pattern [11].
Intratumor clonal heterogeneity has been proposed as a major attribute underlying tumor evolution, progression, and resistance to chemotherapy and radiation.
In contrast, the treatment of advanced well-differentiated NET depends on site of origin, underlying tumor biology, and whether or not the patient is symptomatic.
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However, no explanation was given for the underlying tumor-homing mechanism, which may be in part attributed to the intraperitoneal injection route.
To test this hypothesis, we used experimental metastasis and CTL adoptive transfer mouse models to elucidate the molecular mechanisms underlying tumor-specific CTL persistence in the tumor microenvironment.
The mechanism underlying tumor-promoting effect of stroma is still not fully understood.
Moreover, the mechanism underlying tumor-promoting effect of tumor in EOC was still not explored by us.
Despite these findings, radiological progression remains an important measure of the underlying tumor-growth rate and activity of antitumor therapy.
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