Sentence examples for underlying trail from inspiring English sources
The molecular mechanisms underlying TRAIL resistance in tumor cells have been an active research area.
Overexpression of c-FLIP has been suggested to be the key mechanism underlying TRAIL resistance in pancreatic cancer [13], [17].
The mechanisms underlying TRAIL resistance are complex.
The molecular mechanism underlying TRAIL sensitization by cisplatin appeared similar to the one responsible for UVB-induced TRAIL sensitization.
In our study, we investigated the molecular mechanisms underlying TRAIL resistance in CRC cells with a mutant PIK3CA (PIK3CA-mut) gene.
Our analyses suggest that the mechanism underlying TRAIL sensitivity is based on the association, within lipid microdomains, of DRs DR4 with a specific ganglioside, that is, the monosialoganglioside GM3.
The underlying determinants of TRAIL sensitivity are not clearly understood.
To elucidate the molecular mechanisms underlying sensitization to TRAIL upon uPA knockdown, its dependence on caspase activity was analyzed.
To identify the mechanisms underlying sensitization to TRAIL by thioridazine, we examined the expression levels of apoptosis-related proteins, including the Bcl-2 family, IAP family, constituents of DISC (FADD and cellular FLICE-inhibitory protein (c-FLIP(L)), and DRs in thioridazine-treated Caki cells.
They enable you to read dispositionally rather than methodically; that is, you build as you read a sense of the habits of mind underlying the associative trails, the jolts and starts, of each essay's progress.
Potential mechanisms underlying sensitisation to TRAIL-induced apoptosis include inhibition of NF- κB signalling, stabilisation of BH3-only proteins, p53 or p21, upregulation of TRAIL-Rs and enhanced stability of caspase-8.
