Our study adds eight additional studies to the previous quantitative synthesis, along with a formal assessment of the potential selection bias underlying the summary estimate.
The values underlying the summary plots such as the meta-gene and meta-enhancer plots in Figures 3D and 4B, Figure 3 figure supplement 2B, Figure 4 figure supplement 1B, 2A,C were generated with the computeMatrix module of the deepTools package using either 'reference-point' or 'scale-regions' mode and were visualized with the R package ggplots2.
Dose-response relationships were assessed by estimation of a trend underlying the summary effect estimates of the 25(OH D quintiles applying the best fitting equation of the form y=m x b (y, effect estimate; m, constant1, x=number of quintile (that is, 1, 2, 3, 4, or 5), b=constant2).
In this contribution we provide a summary of our findings, as well as previously unpublished details of the numerical algorithm underlying this novel formulation.
The data underlying this graph are shown in Figure 6 figure supplement 4. DOI: http://dx.doi.org/10.7554/eLife.02630.024 10.7554/eLiFigure30.025 Figure 6 figure supplement 1. Summary of Sk/Sp hybrid and pure species diploid meiotic phenotypes and distribution of alleles in their progeny.
"The psychology underlying this is totally wrong.
The confusion underlying this remark is staggering.
The mechanism underlying this phenomenon is unclear.
In summary, we have shown that VEGF xxx b proteins are downregulated in metastatic but not in nonmetastatic malignant melanomas, but the mechanism underlying this is not known.
The global improvements in nutrition may be encouraging, but substantial inequalities probably underlie the summary figures.
