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The mechanism underlying the specificity of synergy between LMPO and chitinase deserves further study.
Further characterization of the genes identified in our study may enhance our understanding of the molecular basis underlying the specificity of diseases caused by the three fusion proteins.
To determine if there was a particularity in FoxO3 sequence underlying the specificity of Set9 towards FoxO3, we aligned the region surrounding FoxO3 K271 with that of other mammalian and non-mammalian FoxO family members.
As a mechanism underlying the specificity of individual LPTCs for particular patterns of optic flow, it has been presumed that LPTCs sample local inputs with different preferred direction across their dendrites [ 6, 7].
The levels of α-Tubulin were similar in all transfected cells and α-Tubulin was not precipitated by anti-myc, further underlying the specificity of the mBRI2/mAPP interaction.
An important goal of future research is to decipher the molecular mechanisms underlying the specificity of factor-promoter interaction, both at the level of core promoter recognition and at the level of protein-protein interactions.
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The IGT also proposes a number of computational principles that underlie the specificity of perceptual grouping, which could inspire more specific implementations as neural network models or in machine vision.
This reinforces the difficulty in assigning specific function to these Arf-GEFs and underlies the specificity of the Golgi fragmentation phenotype on suppression of BIG1.
IP6 at the peripheral binding site interacts with the primary PH-TH module to which it is bound through the phosphates at positions 1, 2, 3, and 4. None of the inositol phosphates used in our experiments, other than IP6, can fully satisfy this criterion, which may underlie the specificity of the PH-TH module for IP6.
The mechanisms underlying the regional specificity of NIA of mutant DRPLA proteins, however, remain to be elucidated.
Thus, evasion of complement-mediated immunity appears to be a common mechanism underlying the host specificity of many pathogenic bacteria that colonize the mucosal surfaces of humans.
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