Sentence examples for underlying the rationale from inspiring English sources

This article examines the literature underlying the rationale for molecular therapies for ADPKD and reviews the existing clinical evidence for their indication for human patients with the disease.

It is also the foundation underlying the rationale for the company's recent stock buyback.

By the time the Afghan presidential elections exploded into a showcase of abject corruption and illegitimacy, these activists had laid the groundwork that helped the American people interpret the events of late August 2009 as a serious blow to the assumptions underlying the rationale for a deep military involvement.

This is not surprising once the probe template annealing is correctly attained, which actually is the main assumption underlying the rationale of the method.

There need be no single principle that underlies the rationale: it may rest on a number of factors that reinforce the conclusion.

Forced expression of PD-1 and PD-L1 by T cells and tumor cells underlies the rationale that blockade of the PD-1 pathway would restore tumor-specific T-cell function to eliminate tumor cells (Curiel et al., 2003).

This proverb underlies the rationale to use viruses that specifically attack bacteria (that is bacteriophages, or phages for short) to treat bacterial infections.

Despite the shortage of studies reporting a causal link between joint loading and structural disease progression, the conjectured relationship underlies the rationale for many clinical efforts to reduce knee loading during walking in attempts to retard disease progression.

This may contribute to hypotension and underlie the rationale for treatment of CIRCI with fludrocortisone, because inhibition of 11β-hydroxylase increases levels of 11β-deoxycorticosterone by inhibiting conversion to corticosterone and from there to aldosterone [ 2, 16, 18- 20, 30, 31].

However, a number of authors have started to question some of the assumptions that underlie the rationale of KT, including basic concepts, such as the nature of the "evidence" or knowledge that is supposed to be "translated" [ 33], as well as the role of context, and user values and beliefs, in influencing behaviours and decisions [ 34, 35].

This underlies the rationale to use the combined occurrence of low HDL-C and high TG as dichotomic variable in order to assess AD prevalence in a population, while the log TG /HDL-C appears more appropriate to rank AD severity as a continuous variablog TG /HDL-C individuappears].