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Another mechanism underlying the modification of chromatin structure relies on the activity of the SWI/SNF-related ATP-dependent chromatin remodeling complexes that control the accessibility of DNA sequences to transcription factors.
Particularly in the central mechanism underlying the modification of synaptic strength, this GPR-dependent aspect appears to be obvious.
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Similarly, after menopause, women present an increased BMI, waist circumference, and glycemia, which might underlie the modifications of cardiometabolic profile.
In response to these limitations, further experiments should focus on the mechanisms that underlie the modifications of these biomarkers in severely affected dogs and humans.
Details about the chemical reactions underlying the covalent modification of amino acid side chains and backbone cleavage can be found in a detailed review by Xu and Chance [ 4].
The exact molecular mechanisms that underlie the adaptive modifications of liver physiology during expression of the FEO and in response to the DRF protocol are not known.
The molecular mechanisms that underlie the epigenetic modifications of phenotype are increasingly well understood.
Insight into the mechanisms underlying the dynamics of histone modification pattern formation is largely lacking, mainly because many factors act in concert and simultaneous measurement or control of these factors is still experimentally challenging.
Future studies are warranted to replicate the effect modification results of the SNPs and to assess the potential mechanisms underlying the effect modifications (e.g., altered expression).
DNA methylation (DNAm) is a chemical modification underlying the epigenetic regulation of gene expression [ 1, 2].
The toolkit provides a way to identify genomic modifications underlying the specific phenotype of the mutant and to understand potential biological effects of the mutation.
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