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This observation offers a new biological basis for the mechanisms underlying the action of these polyphenols in cancer radiotherapy.
Jezegou, A. et al. Heptahelical protein PQLC2 is a lysosomal cationic amino acid exporter underlying the action of cysteamine in cystinosis therapy.
This work thus points at cross-species manipulation of gene expression as, potentially, an underappreciated mechanism underlying the action of biological control agents.
A thorough understanding of the mechanisms underlying the action of various vaccines is essential if we are to develop a universal influenza vaccine.
In addition to the regulation of social and emotional behaviors, the hypothalamic neuropeptide oxytocin has been shown to stimulate neurogenesis in adult dentate gyrus; however, the mechanisms underlying the action of oxytocin are still unclear.
However, the molecular details underlying the action of this agent remain incompletely understood, and a molecular view of PD-1/PD-L1 interactions in general is only beginning to emerge.
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The cellular mechanism underlying the actions of 5-HT and fluoxetine in PFC has been largely unknown.
A gain of function has therefore been suggested as underlying the actions of this mutation too.
A possible role of NO in the pathogenic mechanism underlying the actions of MPTP has received considerable attention.
Furthermore, the failure of squalene to influence the response suggested that the mechanism underlying the actions of the statins was cholesterol independent.
However, the mechanisms underlying the actions of GLN remain unclear, and may depend upon the route of GLN administration and the model of acute lung injury (ALI) used.
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