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Orme, I. Cellular and genetic mechanisms underlying susceptibility of animal models to tuberculosis infection.
Krishnan, V. et al. Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions.
Despite intensive study, much of the genetic architecture underlying susceptibility to the disease remains to be defined.
Variation in gene expression is an important mechanism underlying susceptibility to complex disease and traits.
Genetic association studies are central to efforts to identify and characterise genomic variants underlying susceptibility to multifactorial disease.
Most of the genetic architecture underlying susceptibility to the disease remains to be defined and is anticipated to require the analysis of sample sizes that are beyond the numbers currently available to individual research groups.
The integration of carefully designed genetic linkage and association studies with gene expression experiments in human and animal models of diabetic kidney disease appear to offer great promise for detecting the molecular mechanisms underlying susceptibility to DN.
The observed pattern of familial recurrence risk has long suggested that multiple variants are involved, but it has proven difficult to identify individual risk variants and little has been established about the genetic architecture underlying susceptibility.
The rapid pace of methodological development in this area has been coupled with an accumulation of experimental data that makes the elucidation of complex biological networks underlying susceptibility to these common inflammatory diseases a reasonable goal in the near future.
In addition to well-established syndromes of cancer predisposition, much remains to be discovered about the genetic variation underlying susceptibility to common malignancies.
An integrated molecular analysis of genes and regulatory regions at these loci provided evidence for functional mechanisms underlying susceptibility and implicated CHMP4C in the pathogenesis of ovarian cancer.
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