While the possibility of some real change in risk cannot be excluded, for many cancer subtypes the estimated timing of underlying step changes in rate appeared to correspond with changes in diagnosis or registration procedures.
Using national registry data from Great Britain, we estimated the timing of assumed underlying step changes in rate, and compared this with relevant innovations in diagnosis and registration procedure.
We provide here a comprehensive study of the different steps underlying the formation of the zebrafish subintestinal plexus and its relationship to the vascularization of the GI tract (Fig. 9).
The latter dynamics were found to be strongly influenced by addition of synthetic surfactants, consistent with our proposal that the rate-limiting step underlying the response of the LC was the transfer of lipids from captured vesicles into the protein-decorated LC interface.
Furthermore, we have taken advantage of the flexibility of pseudotyped particles to investigate the molecular mechanisms underlying initial steps of virus entry following cell attachment.
Furthermore, by combining these imaging techniques with pharmacology, the signalling mechanisms underlying different steps of structural and functional plasticity of dendritic spines have been revealed.
The spontaneous metastasis model has the advantage of recapitulating all the important steps of the entire metastatic cascade, providing a unique platform to dissect the molecular mechanisms underlying all of the individual steps of metastasis.
The exact molecular mechanism underlying one of the first steps in signal transduction, namely the recruitment of signalling components to the cytoplasmic parts of cytokine receptors, remains elusive.
Such ongoing speciation is happening under clinal sympatry, yet the very ecological processes underlying the initial steps of divergence presumably involve the occupation of marginal habitats and may happen under allopatry of the genetic variants responsible for the niche shift.
Here, we investigate the different steps underlying the embryonic development of the subintestinal plexus and provide a thorough characterization of its interactions with the nascent digestive system.
