Because higher cell density not only decreased cell spreading, but also would be expected to increase the level of paracrine (diffusible) and juxtacrine (cell cell contact) signaling from neighboring cells, these data suggest the presence of a pro-osteogenic signal with increasing seeding density that opposes and masks the underlying spreading-dependent osteogenic signal.
On the other hand, for the purpose of elegant spectral coexistence, the underlay spreading spectrum (SS) of USCS should also be strictly restricted by regulatory emission mask [13].
However, its transitory mydriasis with a preserved light reflex could be related to a central hyperactivity of the sympathetic system starting from the hypothalamic region if we accept the hypothesis that the mechanism underlying the spreading depression could be localized not only in the cerebral cortex but even in other brain areas as suggested by other atypical auras [7].
This defect was found to impair leading edge protrusion, underlying cell spreading, migration and cholesterol-dependent Salmonella invasion.
To analyze the fundamental mechanisms underlying PRV spreading and pathogenesis, it is critical to gain a comprehensive understanding of the roles of each gene and their products during viral replication.
The cellular pathways underlying prions spread from the sites of prions infection/peripheral replication to the central nervous system are still not elucidated.
This would be the analogy with the mechanism initially suggested to underlie laterally spreading depolarization (Grinvald et al. 1994; Roland et al. 2006).
Symmetric cell divisions underlie tissue spreading or directional tissue morphogenesis, depending on whether the spindle is randomly oriented within the epithelial plane (z axis) or assumes a fixed planar orientation.
Interneuronal α-synuclein transfer, which underlies protein spreading from the medulla oblongata to more rostral brain regions in this rat model, is not a mere consequence of passive release from damaged or dead neurons.
Generation of a more complete catalogue of genes that escape from XCI would allow assessment of their contribution to disease, and the characterization of escape genes and their chromatin neighbourhood should also provide insights into factors underlying the spread of XCI and, by extension, the spread of heterochromatin across the genome.
There, tau pathology spreads synaptically from neuron to neuron [ 52, 60, 114], which may be the mechanism underlying the specific spreading pattern of tau pathology in Alzheimer's disease [ 25].
