Sentence examples for underlying role for from inspiring English sources

This association became nonsignificant after adjustment for leptin, which may indicate an underlying role for leptin, or overall fat mass as expressed by leptin, to mediate this association.

This result was robust when compared with simulations using random SNPs, and may arise from an important underlying role for homologous genes in complex diseases.

These results suggest an underlying role for genes in specific clusters in potentiating age- and sex-related differences in susceptibility to adverse health effects.

Any underlying role for CD4+PD-1+ T cells in terms of responsiveness to chemotherapy remains to be explored; we observed neither a supporting effect on cancer cell proliferation nor a suppressive effect on IFN-γ-secreting activated cytotoxic T cells in vitro (data not shown).

Because ion channels and more specifically anion channels assume a crucial position in cells, an understanding about the underlying role(s) for ion channels in the signalling pathway leading to programmed cell death is a subject that warrants future investigation.

Enhanced MMP-10 expression has been linked to poor clinical prognosis in some cancers, however, mechanisms underlying a role for MMP-10 in tumorigenesis and progression remain largely unknown.

And while the presence of Rb in the cytoplasm of cells in skeletal muscles can have damaging consequences, we still do not know if there is an underlying physiological role for Rb in the healthy turnover sarcomeres.

Finally, recent studies have involved survivin in cell motility, which may underlie a role for this protein in promoting melanoma metastasis [ 10- 12].

In addition, the functional enrichment analysis of crosstalk motifs was performed to investigate the underlying biological roles for crosstalk motifs in human PINs (Methods in Additional file 1).

In summary, the combined work from the two papers has helped to reveal the mechanism (in terms of DNA sequence requirements and deacetylation targets) underlying the critical role for Sir2 in establishing and maintaining centromeric heterochromatin.

In this review, we will discuss some known actions of IL-1β and IL-18 on leukocyte and vessel wall function that could potentially underlie a prohypertensive role for these cytokines.