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Accordingly, the underlying response rate of the survey was unknown.
If responses are observed, then single-agent activity is indicated and the underlying response rate can be estimated with the precision of approximately ±13%.
These findings show that broad ranges of exposure-outcome relationships estimated from two studies of the same population remained consistent regardless of the underlying response rate or mode of questionnaire administration.
16 Exposure outcome relationships estimated from the 45 and Up Study data have been shown to be consistent with another large study of the same population, regardless of the underlying response rate or mode of questionnaire administration.
The sample size in such a selection design is selected to assure that if one of the treatments has an underlying response rate which is clearly superior to that of the other treatments; it will be selected with high probability.
If no responses are observed, the exact binomial 95% upper confidence limit on the response rate is 9.5%, indicating that such an outcome would provide 95% confidence that the underlying response rate is below this nominal level of activity.
Similar(54)
These SNPs are thus promising candidates for causal genetic factors underlying response to selection on metabolic rate.
Here, to investigate the mechanism underlying differential response rates to melphalan therapy, we assessed the epigenetic changes and the alteration of DDR signals in malignant BMPCs and PBMCs of newly diagnosed MM patients.
Elevated IFP up to 25 mmHg has been described in lung tumors, which may underlie low response rates to chemotherapy [ 11].
In patients with underlying AOSD, the response rate among those who received IV CYC was high as compared with those who received cyclosporine (100% versus 66.7%) or IVIG (100% versus 0%), although statistical analysis did not show significant differences.
Even though such differences at tissue level cannot be captured by the analysis of blood or plasma data, pharmacodynamic variants may ultimately underlie differences in response rates.
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