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Unfortunately, the mechanisms underlying resistance of castration-resistant prostate cancer cells to chemotherapy-mediated apoptosis are still unknown.
These findings suggest that combined ALK and SHP2 inhibition may be a promising therapeutic strategy for resistant cancers driven by several different ALK-independent mechanisms underlying resistance.
However, the connection between the STDP process and the physical mechanisms underlying resistance changes in these memristors is unclear7.
Of tumors that develop resistance to highly potent second-generation ALK inhibitors, approximately half harbor resistance mutations in ALK, while the other half have other mechanisms underlying resistance.
Advances in insect biochemistry and genomics are casting light on underlying resistance mutations and mechanisms, and providing sophisticated tools for diagnosing changes in susceptibility over time and space.
Increasing the response rates to ICBs requires insight into the mechanisms underlying resistance and the subsequent design of rational therapeutic combinations on a per patient basis.
Our findings shed light on the mechanisms underlying resistance to D. mali and provide important clues for designing strategies to curb the effects of this disease.
Thus, there might be other genes underlying resistance in these genotypes.
Understanding the mechanisms underlying resistance to BPH is essential for developing appropriate breeding strategies (Qiu et al. 2012).
The results of the GWAS validated known genes underlying resistance and identified novel loci that provide useful targets for further investigation.
Differences in the resistance loci detected using two germplasm sets demonstrate the differentiation of loci underlying resistance in terms of the distinct population structure in rice.
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