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This anatomical particularity could be useful in liver investigations, for example, into the mechanisms underlying regeneration of the normal liver.
Moisture availability and opening size appear to be important factors underlying regeneration success in this study.
Together, these discoveries provide a foundation for describing the principles underlying regeneration of complex, multi-tissue structures.
Studies of the naturally existing and genetically modified models of regeneration certainly enhance knowledge of the molecular and cellular mechanisms underlying regeneration.
Moreover, we reflect on the necessity of adequate models to truly grasp a fundamental understanding of the immunological processes underlying regeneration in a clinically relevant context.
In multicellular organisms, dedifferentiation is an important process underlying regeneration and the formation of new stem cell lineages [52].
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Similar gene expression programs may underlie regeneration of vertebrate appendages such as fish fins and tetrapod limbs.
Thus, we have preliminary evidence that an essentially complete innate immune response occurs in the leech CNS, especially after mechanical damage, such as a nerve crush, during the complex processes that underlie regeneration.
We analyzed multiple published regeneration profiles to identify common organizational principles underlying liver regeneration across distinct tissue response phenotypes.
The reason is the development of genomic tools to analyse its regeneration process from a molecular perspective and the demonstration that the feature underlying its regeneration potential is the existence of a unique population of adult totipotent stem cells, known as neoblasts [ 5, 6].
As shown by the Greek myth of Prometheus and the liver, human beings have known that the liver can regenerate itself since before the Common Era, although the mechanism underlying liver regeneration has remained largely unknown (Chen & Chen 1994).
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