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However, these mice show memory deficits as early as two months of age, suggesting that the genes underlying reference and working memory in these mice cause deficits from an early age.
However, as mentioned before, successful plant species identification relies to a large degree also on the underlying reference database and bioinformatical classification algorithm.
In addition, specialist editorial tools and data maintenance procedures are required, to firstly add the value-added information to the original dataset and to subsequently maintain both dataset and meta-data in line with changes to our understanding of underlying reference resources such as genome/protein sequences or updates to the ontologies used to annotate the information.
From very early on, General Idea used fashion as an underlying reference, like in the elaborate performance "Ms. General Idea Pageant 1971".
Therefore, the underlying reference frame needs to assure the same accuracy.
With derivatives, the purchaser enters a contract that allows him or her to participate in the market movement of the underlying reference obligation or physical security.
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The validation process is a practical way to better harmonise models that diverge due to necessary flexibility left open by the underlying formal reference model definitions.
All results are interlinked with the underlying biomedical reference databases and also with the MEDLINE documents from which the evidence has been extracted (c.f. Figure 5).
Unlike the COSMIC templates, the openEHR archetypes assume an underlying explicit Reference Model (RM) whereas in COSMIC templates, the notion of the underlying information model to process the template constraints is implicit.
However, there are corresponding downsides: authors may not want to take the time to record their findings in detail, and they may not have the cross-disciplinary bioinformatics expertise to link findings to the underlying biological reference databases.
Furthermore, we wanted to discuss whether the archetype team review process can improve the semantic quality of archetypes beyond what is formally defined by the underlying openEHR reference model.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com