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Patients often had underlying malignancy and the highest rates of mortality were associated with underlying pneumonia.
Alcoholic patients develop complications in a high proportion of patients, which often consists of cardiorespiratory failure due to underlying pneumonia.
They are especially at risk for cardiorespiratory failure due to underlying pneumonia, and therefore, aggressive supportive care may be crucial in the treatment of these patients.
This finding is in line with the high proportion of patients with underlying pneumonia present (46%) and implies that optimal supportive care may be crucial in the treatment of alcoholic patients with bacterial meningitis.
Patients were male in a higher proportion of alcoholic patients (22 of 27 [82%] vs 319 of 659 [48%], P = 0.001) and underlying pneumonia was more often present in alcoholic patients (11 of 27 [41%] vs 69 of 659 [11%], P<0.001).
Many of these patients would have received aminoglycosides for other indications such as underlying pneumonia.
Similar(40)
Chest tubes are used first-line when pneumothorax occurs in people with AIDS, usually due to underlying pneumocystis pneumonia (PCP), as this condition is associated with prolonged air leakage.
Those with underlying conditions – pneumonia, for example – receive the necessary medicines.
Most studies on the mechanism underlying bacterial pneumonia following influenza have focused on impaired host defense against secondary infection with an unrelated pathogen.
The phenomenon that K. pneumoniae has a preference to infect immunocompromised populations, especially seniors suggests that the outcomes of K. pneumoniae infection depend on the pathogen-host interactions, but up to now, the molecular mechanisms underlying K. pneumoniae-host interactions remain largely unknown.
The majority of the patients were elderly (over 65 years old; mean overall age 66.7 ± 15.2 years) and had severe pneumonia; underlying diseases were recognized at a high rate in patients with severe pneumonia (P < 0.05) and in those classified as elderly (P < 0.0001).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com