However, current therapies are designed to target the pathogen rather than the underlying pathogenic mechanisms responsible for the manifestation of the pathology.
However, the underlying pathogenic mechanisms are unclear.
Preeclampsia is a complex syndrome with variable phenotypes that suggest differing underlying pathogenic pathways.
However, the molecular mechanisms underlying pathogenic links between diet and particular oncogenic mutations in human cancers remain unclear.
Despite enormous efforts dedicated to the understanding of the underlying pathogenic mechanisms, AKI continues to be a therapeutic challenge with no definitive and specific treatment available yet to rescue kidney injury after AKI.
These observations provide proof of concept that identifying the target antigens in tissue-specific antibody-mediated autoimmune diseases is important, not only to understand their underlying pathogenic mechanisms, but also to correctly diagnose and treat affected patients.
Genetic variants of MIP have been associated with inherited and age-related forms of cataract; however, the underlying pathogenic mechanisms are unclear.
A detailed knowledge of the underlying pathogenic mechanisms is necessary for developing new, more specific, and effective therapeutic strategies aimed at delaying the onset and slowing disease progression.
Like primary irritant contact dermatitis, it can be produced and studied under controlled conditions, and therefore more is known about the underlying pathogenic mechanisms.
Therefore, research on CAM function will help to provide a better understanding of the mechanisms underlying pathogenic neurological disorders.
Observational studies have enabled to identify risk factors of CINM related both to the critical illness and to the ICU management, giving clues to underlying pathogenic mechanisms.
