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Potential weaknesses include the fact that only one baseline random urine sample was taken and that ACR was not confirmed with a morning urine sample, and the necessary 'lumping' of categories of death into mutually exclusive categories by primary or underlying cause, whereas most natural deaths actually had more than one underlying morbidity or contributory condition.
The mortality associations have their basis in underlying morbidity, but will only partially reflect the overall morbidity problems of obesity, because they involve several health problems not associated with increased mortality, e.g. chronic musculoskeletal disorders.
Pharmaceutical utilization is a proxy for underlying morbidity.
The model also included adjustment for underlying morbidity using an age-adjusted Charlson score.
First, studies rely largely on self-reported survey data, and second there is a lack of attention to underlying morbidity.
The study was able to examine underlying morbidity in terms of self-reported symptoms, chronic conditions and self-assessed health.
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Because he is over 70 and overweight, he represents the cohort of Americans most in danger right now: the elderly with underlying morbidities.
Treatment of Fournier's gangrene, regardless of etiology, involves aggressive debridement, intravenous antibiotics, fluid resuscitation and management of underlying morbidities such as diabetes, if present, by controlling the blood sugar [4],[5].
Rather, the underlying morbidities of the inpatient study population or exposure to the hospital environment likely account for differences observed between healthy and inpatient cohorts.
We propose that the underlying morbidities of the inpatient population and/or their exposure to the hospital environment caused a transition from a "healthy" nasal microbiota to either an S. aureus- or S. epidermidis dominated microbiota (Fig. 10).
Debridement or replacement of prosthetic material is generally considered necessary for cure, which was not performed in our case given her underlying morbidities.
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