The results suggest that BRCA2 mutations may underlie marked genomic instability resulting in extensive gene mutations in the cancer cells, and this instability may also be responsible for increased vulnerability to DNA-damaging chemotherapies.
Beauty, purpose and in general value especially when conjoined with delicate complexity were popular underlying intuitive marks.
However, the pathology underlying the marked left ventricular dilatation remains unclear.
The customer balances are typically fully collateralized by the underlying securities, marked to market on a daily basis, and in most cases there is a 50% margin on deposits.
However, the molecular mechanisms underlying the marked changes in glia remain elusive.
To study the basis underlying the marked differences in the cytotoxic activities observed for these drugs under severe hypoxia, we assessed whether or not these cytotoxic drugs can elicit their downstream effects under DMOG treatment.
Evidence for this mechanism is particularly clear for dislocations initiated at reentrant corners and, although not readily amenable to direct observation, similar behavior likely underlies marked increase in dislocation densities observed with transition from Regime I to Regime II in crystallization from the melt.
Here we have shown that recent bottleneck events within the three studied Jewish populations (Ash, Seph and NAF), underlie marked differences in mtDNA diversity in three ethnically-related Jewish populations, resulting in increased frequency of genotypes in some populations, some of which may act as susceptibility factors to T2DM complications.
In contrast to the K27M mutation, broad changes in DNA methylation and histone marks underlying G34R/V induced tumorigenesis are less clear.
In this study, we set out to unravel the epigenetic marks underlying EpCAM overexpression in ovarian cancer.
