These lines were selected considering the resistance response and their genotypes (Xana or Cornell 49242) for underlying markers located in the putative position of the genetic map in which the candidate gene was located.
This is the first demonstration, to our knowledge, that quantitative imaging of tumor vascular permeability to a nanoprobe represents a form of a surrogate, functional biomarker of underlying molecular markers of angiogenesis.
We next investigated the changes of underlying molecular markers of EMT and found that doxorubicin significantly decreased E-cadherin expression and upregulated the mesenchymal marker vimentin in BIU-87 cells (Fig. 3b).
Moreover, recent research has suggested that RA patients can continue to experience significant levels of pain even when underlying disease markers of RA (i.e. DAS-28) are controlled by modern therapeutic regimens [ 6, 7].
Modeling the complexity of the psychiatric syndrome of pre-clinical HD in an animal model is therefore important both for the designing of novel specific treatments and for increasing our understanding of the neurobiological mechanisms underlying these early markers of HD pathology.
In the absence of brain AChE inhibition, dietary CPF exposure throughout pregnancy and lactation modifies social behavior patterns and mRNA expression of underlying neuroendocrine markers in the adult offspring.
The research team identified 108 genetic markers underlying risk of developing schizophrenia, 83 of which had never been identified before.
As more genomes are sequenced, it becomes increasingly feasible to map genetically identified QTLs from various breeding populations (e.g. in rice and other crops) based on the sequence alignment of the genetic markers flanking the borders of the QTL region or, if desired, only the markers underlying the peak of the resolved QTL.
Whether these SNPs in or close to specific genes are part of the underlying pathogenesis or simply markers of the disease is still not known, although some of these variants have been linked to impaired β-cell function and insulin secretion [11].
The markers of underlying pathology in all these pathways can serve as markers for AD.
