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These theories also indicate underlying linkages with human rights, which also grapple with these themes in relation to health, particularly regarding utilitarian public health measures that violate individual and collective interests.
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Briefly, as defined in the Methods section, the minP test provides a gene region-level summary of association by assessing statistical significance of the smallest p-trend within each gene region by permutation-based resampling methods and automatically adjusts for the number of tag SNPs tested within that gene region and the underlying linkage disequilibrium pattern.
Those regions underlying linkage peaks are narrowed down by fine mapping, so that candidate gene analyses can be pursued.
Both estimators rely on the underlying linkage disequilibrium (LD) between the causal variant and the genotyped SNP.
Because of differences in variant frequency and underlying linkage disequilibrium (LD) structure between ancestral populations, the relationship between rs10510181 and a pathogenic variant may be influenced.
The use of actual data provides us an opportunity to unequivocally characterize the underlying linkage disequilibrium structure in these two populations.
The underlying linkage disequilibrium, as demonstrated with both D′ = 0.83 and the haplotype structure, indicate that the variants are well correlated and differ slightly in minor allele frequency.
This method is an extension of the Bonferroni correction that accounts for the underlying linkage disequilibrium or dependence in dense SNP panels.
Analysis of the sources of variation in imputation accuracy revealed dependence both on the minor allele frequency of the single nucleotide polymorphisms (SNPs) being imputed and on the underlying linkage disequilibrium structure.
Multilocus models of association fully take account of the underlying linkage disequilibrium between SNPs, as well as the correlation in the effects of the SNPs; thus, it may be more powerful to detect the association than single-locus tests.
Because the loci are in close proximity to each other, haplotype analysis was performed to investigate whether underlying linkage disequilibrium (LD) contributed to the non-independence of these associations.
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