Sentence examples for underlying linkage from inspiring English sources
Briefly, as defined in the Methods section, the minP test provides a gene region-level summary of association by assessing statistical significance of the smallest p-trend within each gene region by permutation-based resampling methods and automatically adjusts for the number of tag SNPs tested within that gene region and the underlying linkage disequilibrium pattern.
Those regions underlying linkage peaks are narrowed down by fine mapping, so that candidate gene analyses can be pursued.
Both estimators rely on the underlying linkage disequilibrium (LD) between the causal variant and the genotyped SNP.
Because of differences in variant frequency and underlying linkage disequilibrium (LD) structure between ancestral populations, the relationship between rs10510181 and a pathogenic variant may be influenced.
The use of actual data provides us an opportunity to unequivocally characterize the underlying linkage disequilibrium structure in these two populations.
The underlying linkage disequilibrium, as demonstrated with both D′ = 0.83 and the haplotype structure, indicate that the variants are well correlated and differ slightly in minor allele frequency.
These theories also indicate underlying linkages with human rights, which also grapple with these themes in relation to health, particularly regarding utilitarian public health measures that violate individual and collective interests.
Collectively, despite the presence of suggestive evidence of linkage at multiple chromosomal regions, none overlapped among the African ancestry studies, and the causal genes underlying the linkage peaks, if any, have not been identified.
Identifying the causal variation underlying each linkage score will help to unravel the genetic architecture of these quantitative traits and, by extension, the genetic architecture of cardiovascular risk.
The underlying functional linkage network is shown in Figure 4.
Subsequent gene-based association study was performed to identify potential QTL genes underlying the linkage peak.
