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The estimated heritability of post-challenge survival in Group 1 was 0.42 ± 0.07 on the observed binary scale and 0.58 ± 0.09 on the underlying liability scale, derived from fitting a linear animal model and a sire-dam threshold model, respectively.
They also employed variance in liability explained as an effect size measure, which is similar to our study (but we assume a normal distribution of the underlying liability rather than a logistic distribution).
The binary option estimates SNP effects and variance components on the underlying liability scale.
Endophenotypes refer to quantifiable intermediate constructs that index an underlying liability to a disorder or behavioural trait.
The model is parameterized in terms of variance components and heritability on the underlying liability scale and can be scaled so that the phenotypic variance is 1.
As with POP 1, these heritabilities were transformed on to the underlying liability scale, and a heritability of ~0.4 was obtained using both models (Table 1).
Similar(25)
Still, the model with underlying liabilities seems to be the most appropriate.
These secondary approaches are similar to the direct use of discrete numerals instead of underlying liabilities in the analysis of discrete variables [ 9].
Because deficits in certain dimensions of cognitive ability are thought to underlie liability to schizophrenia, the project also examines cognitive abilities in individuals affected by schizophrenia and their extended family members.
In Gianola and Simianer [ 10], "events" were included as linear effects underlying the liability.
The mechanism underlying this liability trait may also be valid for the (patho-) physiological processes that take place during muscle damage due to biochemical and physical burden at prolonged exercises.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com