The transport impairment we observed could therefore underlie later dysfunction.
The molecular mechanism underlying this later finding remains unknown.
This was accompanied by an increased B2 receptor density possibly requiring protein synthesis underlying the later phase of permeability increase (see Figs. 2A and B).
Their proposal, that a disruption of brain development during early life underlies the later emergence of psychosis during later adolescence or early adulthood, has become well established in the field, although the specific aetiological mechanisms operating in development of the illness remain to be determined.
Future validation efforts may be able to identify which of the two genes (DDX40 or YPEL2) underlies this later association signal.
They hardly do it justice, but are valuable as indications of the structural sophistication and pictorial invention underlying Brooks's later nonobjective work.
She calculates that for over-55s, median wealth fell from 5.7 times income in 2007 to 4.6 in 2008, returning to the level of 1995.But while diminished wealth may keep more of the elderly in the office, it merely enhances an underlying trend towards later retirement.
The gene underlying the QTL, later termed PHOSPHORUS-STARVATION TOLERANCE 1 (PSTOL1), was cloned and appeared to encode a receptor-like cytoplasmic kinase (Gamuyao et al. [2012]).
While the first assesses the trend of the vector quantization process towards the underlying distribution, the later is able to detect regions of the map that may become "unused" given some changes in the distribution, e.g., disappearance of clusters.
The hypothesis that the variation in autistic traits could be attributed to a single continuously distributed underlying factor was later confirmed in a clinical sample of patients with ASD and other psychiatric disorders [ 58] and in siblings of children with ASD [ 59].
