In this instance, using the related variant would not fully represent the underlying exposure of interest; it would be better to use the causal variant directly.
Gene products might be different between tissues, but since the underlying susceptibility polymorphisms are ubiquitous it would be theoretically possible to use any tissue to interrogate an individual's susceptibility state.
Firstly, as the mechanisms underlying these observations are unclear, it would be interesting to examine the effects of an oral fat load, intravenous glucose load or calorie free oral load on these varaiables.
To investigate the molecular mechanisms underlying the formation of the OSVZ, it would be useful if multiple genes, such as GFP plus genes of interest, could be co-transfected in progenitor cells of ferrets.
While we believe the assumptions provide results sufficiently approximating the underlying processes, in a joint model it would be worth including the uncertainty about withdrawal as an interval-censored time variable, and this has not been done before.
Howard Archer, chief economist at IHS Global Insight said the underlying trend would be of weaker growth once buy-to-let investors and second-home buyers revert back to the normal trend.
Additional experimental work to constrain the mechanisms underlying deletions would be beneficial to help guide efforts in this direction.
Additionally, a connection to their local language and culture would need to be established, including identifying what the underlying motivations would be for their defection.
A more thorough understanding of the molecular mechanisms underlying LQTS would be very helpful for the pharmaceutical industry.
The benchmark for testing the underlying physiology would be the model likelihood (i.e. evidence), given the data.
