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The principle underlying informed consent personal autonomy presumes that individuals will be given sufficient information to make an informed choice about their participation in research.
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Applying biomarkers in early clinical trials helps identify the most appropriate patients; provides proof of concept for target modulation; helps test the underlying hypothesis; informs the rational selection of dose and schedule; aids decision making, including key go/no go questions; and may explain or predict clinical outcomes.
Human dignity is the underlying concept informing the Universal Declaration of Human Rights and the phrase 'Black Lives Matter'.
That referendum rendered a definitive judgment: the underlying consensus informing U.S. policy since the end of the Cold War has collapsed.
Decisions about the components of the intervention are linked to the underlying theory informing it and the outcomes of interest which are discussed below.
Our experience suggests that both the skill and the underlying attitude informing its application must be addressed, and is best done so longitudinally and reiteratively using different forms of feedback delivery.
The underlying database informs on known and predicted protein-protein interaction and the constructed networks are based on active prediction methods of Neighborhood, Gene Fusion, Co-occurrence, Co-expression, Databases and Textmining.
New approaches for detection of early changes in subclinical periods will afford powerful tools for aiding clinical diagnosis, clarifying underlying mechanisms, and informing neuroprotective interventions to slow or reverse neural injury for a broad spectrum of brain disorders, including bipolar disorder, HIV infection on brain, Alzheimer's disease, Parkinson's disease, etc.
I realize that you can tell a lot about the underlying truths that inform a country, a government or an organization by reading its founding documents.
The failure in the initial reporting on the debate lies not only in ABC's reluctance--and that of its rivals--to interrogate the underlying political judgment informing those questions.
Our results demonstrate the power of an integrative, systematic approach to the analysis of a large gene expression dataset to uncover underlying structure, and inform future eQTL studies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com