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To investigate whether the ovarian response and pregnancy outcomes of patients undergoing in vitro fertilization (IVF) after salpingectomy are affected by the underlying indication for salpingectomy.
Application of this strategy is based on chemical and pharmacological similarities of compounds with clinical evidence of suicidal intent, target or indication classes associated with high incidence of SIB, in vitro neuropharmacological activity profile, in vivo ADME properties, patient population of the underlying indication and regulatory precedents.
An alternative explanation for the observed interaction is the underlying indication.
First we were not able to control for the underlying indication for prescription of opioids.
The underlying indication for opioid use may influence this finding [Gross et al., 2009].
It is possible that the underlying indication for treatment, maternal disease, is the true risk factor.
Similar(42)
These separate cohorts allowed further disentanglement of the effect of drugs from underlying indications for the drugs.
Outputs will include a summative list of unique indications, an evidence map with validity/reliability assessments, a detailed evaluation of the content underlying indications and a RAM-based sorting of indications into chapters subdivided by associated decision variables.
On the other hand, increased risk estimates for gastric cancer with extended follow-up were also seen when compared with H2RA users who are likely to be more similar to PPI users in terms of underlying indications and comorbid conditions, although these estimates were based on small numbers.
15 16 We first sought to assess the characteristics of the clinical evidence underlying supplemental indication approvals in the same way that other investigators have studied such data in original drug approvals: using publicly available FDA medical reviews, which are documents that explore in detail the efficacy and safety of the novel agent demonstrated in clinical trials.
These associations may be explained by the underlying treatment indication being a risk factor for the cancer rather than an independent harmful effect of these agents per se although this is a subject of debate (Langman and Logan 2007; McColl 2006).
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CEO of Professional Science Editing for Scientists @ prosciediting.com