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The precise relationship between electron transport chain flux, ROS generation, and the mitochondrial membrane potential and the mechanisms underlying increases in mitochondrial ROS remain controversial [38].
Hyperfiltration is thought to be a major contributing factor for DN in type 2 diabetes, reflecting underlying increases in intraglomerular pressure, leading to structural changes over time such as mesangial expansion and glomerular basement membrane thickening (21).
Although, C1 neurones do not appear to mediate sympathoexcitation evoked by central actions of CO2, this study provides important guidance for further studies of brain mechanisms underlying increases in sympathetic vasomotor tone, vascular remodelling, and cardiovascular pathology which accompany disruptions in gas exchange in patients with obstructive sleep apnoea.
The earliest published description of histopathologic abnormalities in BPS/IC bladders from patients with Hunner's ulcers described areas where the bladder urothelium was absent and replaced with granulation tissue, as well as underlying increases in inflammatory cells, fibrosis, and capillaries [ 14].
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A genetic association study is needed to reveal the potential genetic variants underlying increased activity of enzymes involved in steroid biosynthesis.
Suggested mechanisms underlying increased postoperative brain metabolism include the recovery of impaired brain activity after the cessation of interictal discharges by surgery.
It is suggested, however, that this is accounted for by the underlying increased exposure of males to injury than that of their female counterparts.
This result suggests enhanced effects of mental stress on pain processing in CTH sufferers may partially operate through different pain mechanisms than those underlying increased pain sensitivity at rest in CTH sufferers.
The mechanisms underlying increased Env expression in the absence of PERK remain unclear.
The exact mechanism underlying increased neurogenesis in the aging dentate gyrus of Psen cDKO mice is unknown.
Thus, these species enable us to study the mechanisms underlying increased lifespan, while excluding other confounding influences.
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