As a consequence, more people die with the disease, but this does not mean that it was necessarily the cause of death, nor that the underlying incidence of Alzheimer's is increasing.
Papers reporting lower rates of overdiagnosis did not report the underlying incidence increase.
All observational studies were estimating overdiagnosis adjusted for annual underlying incidence increases.
5 This pattern may be further complicated by possible temporal changes in the underlying incidence rate.
The annual underlying incidence increase was about 0.5% in Norway and in the United States.
We take two estimates of I, the underlying incidence in the population.
The total number of cases expected in the invited women population on the basis of the underlying incidence was 1051.
Case incidence in the not-yet-invited women group are used as the estimate of the underlying incidence.
To obtain detection rates for the UK National Breast Screening Programme, we need estimates of the underlying incidence.
Such differences derived from the above-mentioned different composition for age and sex of examined population and probably from a different underlying incidence.
Of course, there will be other influences, including changes in underlying incidence because of trends in risk factor exposure and because of overdiagnosis.
