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The relatively high mutation frequencies of these mutations should be approached with some caution though, because underlying founder effects have been reported.
The complete underlying founder haplotype structure of these RILs is known.
The genomes of the original 15 inbred founder lines have been completely resequenced, and the complete underlying founder haplotype structure of all RILs in the panel has been determined via a hidden Markov model (HMM).
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Differences in underlying cancer incidences, founder mutations and environmental exposures could potentially lead to substantial under- or over-prediction of breast cancer risk for women living in different countries.
Gamban started out free for the first two years, and the current charge is a nominal fee reflecting the founders' underlying desire to help problem gamblers while keeping the business sustainable – and they are offering it to students for free.
All topped off by founders' underlying ideological objections to the UK divorcing itself from the EU.
This patient tested negative for several common founder mutations underlying RP in the AJ population, including the Alu insertion in the MAK gene, the p.K42E mutation of DHDDS and the c.1355_136delCA mutation of FAM161A (14– 16).
Streamlined Ventures' founder Ullas Naik said, "Underlying everything, FLYR's strength is in its ability to predict prices accurately up to a month out.
The company's founders recognized that the underlying infrastructure of market-leading e-mail systems such as Microsoft Exchange was originally designed for work groups and had never been upgraded to efficiently support large organizations.
This puts strain on the underlying message-routing architecture, which, the Twitter founders admit, wasn't built to do such heavy lifting.
Three sets of hard-edged practices and underlying attitudes, tracing back to the way the founder had set up the company, emerged consistently.
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CEO of Professional Science Editing for Scientists @ prosciediting.com