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Facial structures develop in late embryonic and early foetal life, driven by complex molecular interactions between surface ectoderm and underlying forebrain and neural crest cells.
Precursor mitosis is followed by migration of neuronal daughter cells into the underlying forebrain, along radial fibers derived from the SZ.
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Recently, we have shown that the mechanism underlying the forebrain defects in the Hesx1-deficient embryos involves the ectopic expression of genes with caudalising activities within the anterior forebrain of the very early mouse embryo [19].
Here, we tested the hypothesis that contextual control of acquisition depends on glutamatergic transmission underlying executive functions in forebrain areas, e.g. by shifting attention to critical cues.
Notably, although many roles for F ezf2 have been described, very little is known about the molecular mechanisms underlying its functions during forebrain development.
Although formalin-induced activity in primary afferent fibers and spinal dorsal horn is well described, the forebrain neural basis underlying each phase of behavior in formalin test has not yet been clarified.
The AVE is a transient organizing center that initiates forebrain specification in the underlying neuroectoderm.
Processes underlying wakefulness influences on respiration partially derive from descending forebrain sites which modify brainstem respiratory patterning; temperature influences from the hypothalamus are commonly cited, but other limbic drives participate.
The molecular mechanisms underlying the anti-neurogenic function of Gro/TLE1 in the developing mammalian forebrain are starting to be characterized.
Otx2, which is expressed in the anterior definitive endoderm (ADE) and underlying anterior neuroectoderm in gastrulation stage (E7.5) embryos, is required for forebrain specification.
Interestingly, alterations in the activation of limbic and forebrain GABAergic circuits have been implicated as potential candidates underlying reduced HPA function during the stress hyporesponsive period (Dent et al., 2007).
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