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The mechanisms underlying fate specification in conjunction with neural tube closure are poorly understood.
To gain insights in underlying fate decisions, it is important to develop computational techniques allowing for a comprehensive analysis of this new type of data.
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In this model, FGF/MAPK signaling both promotes GATA6 expression and inhibits NANOG expression, and differences in FGF/MAPK signaling between cells have been proposed to underlie fate choice from the co-expression state (Bessonnard et al., 2014).
Unfortunately, mechanisms underlying the fate of the vaccine vector co-administered with antigens are still partially uncovered and limit further development of mucosal vaccines.
Human hair follicle mesenchymal stem cells (hHFMSCs) are an important source of cardiovascular tissue engineering for their differentiation potential into smooth muscle cells (SMCs), yet the molecular pathways underlying such fate determination is unclear.
In this paper we propose a model to describe the mechanisms by which undifferentiated cells attain gene configurations underlying cell fate determination during morphogenesis.
Molecular mechanisms underlying cell fate or positional signalling have been revealed through these discontinuous datasets.
This can help to understand the complex feedback mechanisms underlying cell fate control [ 26].
It is also equally possible that the mechanism underlying cell fate determination may involve a stochastic nature.
As such, the question of the regulatory control underlying stochastic fate specification and balance is left open.
The vast data from these approaches provide a framework in which to consider the molecular mechanisms underlying cell fate decisions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com