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By pre-sorting without bias towards specific conditions, the underlying expression levels of each sample dictate membership in a group.
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Our data fit with the definition of the ABCB7 promoter region as an intermediate CpG promoter, but suggest that promoter methylation is unlikely to be the mechanism underlying the reduction in expression levels of ABCB7 observed in RARS.
The additional integration of quantitative protein data of Phase I and Phase II enzymes enables the dynamic analysis of the underlying inter-individual-variability of expression levels of these enzymes.
However, the effect of qGN4.1 in different rice genetic backgrounds and expression levels of the underlying candidate genes is not known.
Correlation of expression levels of genes underlying eQTLs was carried out using Matlab.
Our genome-wide studies of expression levels of genes underlying cis- and trans-eQTLs provide strong support for the hypotheses that the categorisation of eQTLs has a genuine biological basis that can be detected in transcript expression levels, and that trans-eQTL clusters consist of functionally related and co-ordinately regulated transcripts.
The search for changes in expression levels of candidate genes underlying DPN pathological hallmarks has been attempted previously, in either sciatic nerve or DRG compartments of the PNS [14] [22].
To investigate the molecular mechanism underlying the apoptotic pathway, we examined the expression levels of distinct caspases and pro-apoptotic genes.
To explore the underlying mechanisms, the expression level of apoptosis, inflammation and autophagy-related markers in brain tissue were detected with kits or by western blot.
To further investigate the underlying mechanism, the expression level of caspase 3 and bcl 2 were investigated.
To investigate the mechanisms underlying the changes in rhTRAIL sensitivity, alterations in expression levels of targets of interest were measured by Western blot analysis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com