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Subsequently, which knowledge gaps are chosen for experimental research is ultimately a human decision depending on research goals, biological novelty factors, ease of experimental validation, and underlying evidence of the knowledge gap's validity.
"WikiLeaks promotes the ideal of 'scientific journalism' — where the underlying evidence of all articles is available to the reader precisely in order to avoid these type of distortions.
In fact, we could find no underlying evidence of any inappropriate or illegal behavior by Fan Zhang.
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A further limitation is that the strength of underlying evidence to support each of the components of the model is variable.
While grading the strength of recommendations and the quality of underlying evidence enhances the usefulness of clinical guidelines, the profusion of guideline grading systems undermines the value of the grading exercise.
This is illustrated in identified differences in discounting, perspective, time horizons, choice of comparators and strength of underlying evidence.
But three principal considerations drove this discussion, as they should drive any discussion about intervening to prevent future disease: risk/benefit trade-offs; the magnitude of any likely effect; and the quality of underlying evidence.
The strength of underlying evidence was rated strong (RCT or meta-analysis) or limited (not RCT or meta-analysis).
It may require the generation of what we call synthetic constructs, which are the result of a transformation of the underlying evidence into a new conceptual form.
At one point in her ruling, Judge Scheindlin provocatively termed some of the underlying evidence presented by the plaintiffs as a "smoking gun".
"Before pursuing the ultimate penalty, one hopes prosecutors are extremely confident in the integrity of the underlying evidence ― with respect to the crime itself and any aggravating factors.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com