Sentence examples for underlying endpoint from inspiring English sources
If the underlying endpoint is continuous (disease activity, ability), a meaningful cut-off point should be chosen if dichotomizations are preferred.
Since there may be no consistent gene expression profile mechanism underlying a given endpoint phenotype, this indicates that the relationship between a phenotype and gene expression profile should be evaluated prior to exploring a microarray-based predictive model for pathological classification.
Icon arrays only consider the primary efficacy and safety endpoints of underlying studies and do not account for the different clinical consequences associated with each of the outcomes.
Principle 2. Continuous parameters underlying all observed dose response endpoints.
The biological annotation of identified nodes suggests their central role in mediating mechanisms underlying T0901317 effects on disease endpoints, in particular effect on levels of triglyceride and cholesterol in serum and the effect on modulation of inflammatory signals relevant to development of atherosclerosis.
Progression-free survival is the best surrogate endpoint in most solid malignancies, but it is a vulnerable endpoint in HCC since the underlying liver disease is a comorbidity with significant mortality that would potentially bias the evaluation of efficacy in this setting.
Although radiation-induced bystander effects have been confirmed using a variety of endpoints, the mechanism(s) underlying these effects are not well understood, especially for in vivo study.
Towards this end, future work associated with the Dashboard and its underlying data includes exposing an associated SPARQL endpoint [159].
In general, a reliable prediction of cardiotoxicity is hampered due to the still fragmentary understanding of the molecular basis underlying cardiotoxicity, the lack of recognized surrogate endpoints and the availability of adequate pre-clinical test systems.
Assessing epigenomic and other markers underlying altered developmental programming of metabolic functions and endpoints in human studies and in animal models.
The potential risk factors that were studied by at least three papers for several endpoints were patient age and sex, underlying diagnosis, and implant fixation (cemented vs. uncemented).
