Sentence examples for underlying endophenotypes which from inspiring English sources

Trait biomarkers are associated with underlying endophenotypes, which can be used to predict the likelihood of developing disease.

Specific susceptibility gene variants may underly endophenotypes, which in turn may predispose individuals to develop eating disorders and related conditions.

We performed a genome-wide association study of intra-ocular pressure (IOP), an underlying endophenotype for glaucoma.

Irritability might therefore be, through emotional reactivity, an important underlying endophenotype to both oppositional behavior and child depression (Copeland et al. 2009; Stringaris et al. 2012).

Endophenotypes, which are way stations on the pathway between genes and behavior, and can measure objectively (e.g. via neurophysiology, endocrinology, biochemistry etc).

Their multivariate twin analyses suggested that there is significant genetic variance common across candidate endophenotypes which is shared, at least in part, with the externalizing spectrum, but also demonstrated significant genetic effects on externalizing that are unrelated to these endophenotypes, as well as some sex-specific genetic effects.

Of course, the penetrance depends on which phenotype is being assessed - it will be lowest for specific diagnoses, higher for psychiatric illness generally and higher still for neurobiological endophenotypes, which may be apparent even in clinically unaffected carriers.

These vocabularies expressed the underlying realities which made them possible.

This indicates the existence of a metabolic endophenotype, which we speculate could be the pathogenic mechanism underlying the increased risk for Parkinson's disease.

"Look at the underlying markets in which we operate.

"An underlying principle from which 'organic life' grows chaotically.