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If the underlying detoxification mechanisms are also employed in the defence against pathogens, then this may result in the observed differences in resistance.
It is very important to study the underlying detoxification factors and signaling mechanism behind plant defense against biotic stress tolerance.
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These data suggest that P application can enhance the resistance of AM to Cd via polyP chelation, and this represents another mechanism underlying the detoxification of Cd by AM hyphae other than the absorption by hyphae.
Note that PBPK models provide a mechanistic platform for integration and representation of physiological processes underlying drug detoxification within a whole-body context.
As a result of recent advances in our knowledge of the biochemistry underlying endogenous plant detoxification systems and the use of genetic engineering to combine bacterial explosives-detoxifying genes with the phytoremediatory benefits of plants, this technology is now poised for testing in the field and in a wider range of plants, such as poplar and perennial grasses.
In this context, we wanted to investigate the detoxification mechanisms underlying ivermectin resistance by testing four inhibitors for four different detoxification proteins.
However, the underlying mechanisms for inhibitor detoxification and tolerance by fermenting solventogenic Clostridium species remain unclear.
This seems to be the prevailing mechanism underlying the inefficacy of the detoxification regimen and prophylactic treatment in the NR-group.
Here we review the progress in understanding the structural, physiological and molecular mechanisms underlying HM uptake, transport, sequestration and detoxification, as well as the regulation of these processes by signal transduction in response to HM exposure.
The results herein provide a general view of the underlying transcriptional response to gossypol with implications for the detoxification of this plant secondary metabolite.
Thus, further functional research on the PxGSTs is essential to identify the key genes and their roles in xenobiotic detoxification of insects, and understand the mechanisms underlying the insecticide resistance.
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