Sentence examples for underlying deletions from inspiring English sources

Additional experimental work to constrain the mechanisms underlying deletions would be beneficial to help guide efforts in this direction.

The mechanism underlying deletions in 22q11.2DS mainly involves non-allelic homologous recombination (NAHR) between misaligned low copy repeats during gametogenesis (4, 34).

Four central hub TFs showed strongly altered expression levels in response to directly underlying gene copy number mutations (CDC20, GPR123, ZNF365, ZNF488), whereas other hub TFs showed strong underexpression without underlying deletions (e.g. CHD5, HLF, TBR1, THRB, VIP).

A similar phenomenon may be underlying deletion calls in diverse samples that passed quality control cutoffs.

Because of the underlying deletion bias in bacterial genome evolution, and the limited amount of gene flow available to these symbionts, their genomes are minimized.

Recombination between small regions of nonallelic homology has been proposed to underlie deletion and insertion mutations (Mita et al., 1990; Bacman et al., 2009; Fukui and Moraes, 2009).

With regard to biologic basis underlying 13q deletions, miR-15a and miR16-1, located in the minimal deleted region (MDR), have been described to exhibit a tumoral suppressor function in CLL [ 5, 6].

The SNP array offers the possibility to analyse LOH and generate accurate copy number simultaneously in a high-throughput and high-resolution genome-wide manner, thus making it possible to distinguish between LOH regions with underlying hemizygous deletions and those with copy-neutral events (Zhao et al, 2004).

These findings will be important in trying to better understand the mechanisms underlying the deletion of antigen-specific T cells.

Together with the ample among-isolate variation in ND5 deletion heteroplasmy level [ 10] and aging-related phenotypes, we contend that the C. briggsae system offers a powerful and versatile model for understanding the interplay between mitochondrial dysfunction and aging in an evolutionary context, as well as the basic biology underlying mtDNA deletion genetics.

And importantly, this implies that the explanation(s) for the porous nature of the mammalian mitoribosome must be sought in the process -es) underlying the deletion bias of metazoan mitochondrial genomes, and not in unique functional process -esof mitochondrial translation systems.