Sentence examples for underlying defects of from inspiring English sources

Better success for individuals who were older at enrollment might reflect slower progression of the underlying defects of diabetes in those with later onset.

Although pathophysiological differences have been described in the underlying defects of IFG and/or IGT, in general, subjects with IFG and/or IGT already are characterized by impaired insulin sensitivity and β-cell function (25).

"They provide scientific evidence that support our long-standing belief that targeting the underlying defect of C.F. may have a profound effect on the disease".

The implications for their sexual and reproductive function, as well as the underlying defect of insulin resistance, are profound.

The high variability of the floral aberrations indicated that they are the result of underlying defects in the meristem.

These defects may be due to underlying defects in the differentiation of the command interneurons that coordinate forward and backward motility [ 26, 54].

Previously, underlying defects in host defense, especially of neutrophils, have been hypothesized to predispose to infection: cases have been reported in patients with chronic granulomatous disease (13 ) and G6PD deficiency (14 ).

The aberrant ultrastructural profiles observed in our survey of GBM tumors and a review of the current ultrastructural profiles present in the literature suggest the possibility that at present the best possible candidate protein underlying defects in the early stages of ciliogenesis within GBM tumors might involve Cep123.

Most MSI-High tumours result from sporadic hypermethylation of the MLH1 gene promoter[3], but mutation of a DNA mismatch repair enzyme is the underlying defect in cases of hereditary non-polyposis colorectal cancer (HNPCC [4].

The prime goal of treatment of the ocular surface disorders includes relief of symptoms, improvement of visual acuity and quality of life, restoration of ocular surface and tear film, and correction of underlying defects.

Mutations of the low-density lipoprotein (LDL) receptor gene are the underlying defect in the majority of FH patients, but mutations in two other genes can also cause FH, ie, mutations in the apolipoprotein B100 gene and mutations in the pro-protein convertase subtilisin/kexin type 9 gene.