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To explore the mechanisms underlying decreased 5-HT level in Lmx1b iCKO mice, we examined the expression of Tph2, which is a specific enzyme for synthesis of 5-HT in the brain [21].
To evaluate for a possible mechanism underlying decreased variance in gene expression in the blood of children with autism or from older fathers, we analyzed for specific gene expression differences between study groups.
The mechanism underlying decreased expression of IGF1R-targeted miRNA in refractory cells was also addressed.
Molecular mechanisms underlying decreased synthesis of BM components, on the other hand, have rarely been addressed.
Additional studies are needed to evaluate the mechanisms underlying decreased availability of cysteine and glycine in type 2 diabetes.
Loss of mechanical tension appears to be the major factor underlying decreased collagen synthesis in aged skin.
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Finally, pathway analysis suggests that altered regulation of transcription may underlie decreased variance and may increase risk for autism.
Multiple pathways underlie decreased β-cell function and mass, some of which may be shared, with reduction in mass, perhaps a consequence of processes that initially caused dysfunction.
Multiple pathways underlie decreased β-cell function and mass, some of which may be shared and may also be a consequence of processes that initially caused dysfunction.
However, further simulation studies demonstrated that substantial extinction can occur without erasing the signal of an underlying decreasing diversification rate provided the initial speciation rate is high enough [ 74].
The majority of cerebral amyloidosis models do not develop overt neuronal death [ 9] which is a prominent hallmark of human AD and is thought to largely underlie decreases in [F]FDG uptake.
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