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The implication is that the online offerings are merely a spin-off of underlying activity.
"The weakness in underlying activity is likely to be somewhat more persistent than previously expected".
If this was not the case, the activity distribution before PVC would not be correct in the first place, and hence, any PVC technique would obviously not improve our knowledge on the actual, underlying activity distribution (on the contrary, it would even possibly emphasize areas of wrongly placed activity).
However, these useful studies are not designed to further screen mechanisms underlying activity or potential biological outcomes.
Here, we applied high-resolution dual-trap optical tweezers (Abbondanzieri et al., 2005; Moffitt et al., 2009) to determine the mechanism underlying activity of XPD helicase from Ferroplasma acidarmanus.
These maps must be treated cautiously, as distributions of activation can look very different depending on the amplitude and time ranges that are used, and amplitudes at surface electrodes are not a good indication of the source of underlying activity.
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This plasticity is thought to reflect an underlying activity-dependent competition between afferent neurons at the anatomical and physiological levels.
With the affinity matrix at hand, we apply spectral clustering [38] on the nearest neighbor graph to uncover the underlying activities.
These activities and interactions are themselves sustained by underlying activities and interactions among component parts, and so on (see Bechtel and Richardson 2010 [1993]).
Our results with TC10 mutants are also consistent with separate processes underlying activity-dependent and constitutive AMPAR recycling.
Altogether, these studies demonstrate that activity-dependent and constitutive AMPAR recycling can be uncoupled, and thus, appears to be independently regulated, consistent with separate processes underlying activity-dependent and constitutive AMPAR recycling.
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