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Because the data underlying accelerated approval is often less compelling, Genentech had to repeat the trial that got Avastin approved in the first place, showing that its benefits outweighed its risks.
The mechanisms underlying accelerated aging in VDRKO mice are unclear, and with the exception of alopecia (which represents a 1,25D independent effect of VDR), the role of the VDR ligand in these age-related process has yet to be determined.
The mechanism underlying accelerated tumor progression by TACE is unclear.
The mechanisms underlying accelerated brain atrophy in diabetic patients are less clear.
However, the exact mechanisms underlying accelerated atherosclerosis in DM patients are not fully understood.
Our studies suggest that the high-concentration glucose induced disruption of endothelial AJs may also be a mechanism underlying accelerated atherosclerosis in diabetes.
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We interpret this to indicate some of the difference we detected comparing the period before IMCI implementation with that after implementation may be attributable to an underlying accelerating trend, but that it is unlikely that such an accelerating trend can entirely explain the difference we observed.
The mechanism underlying the accelerated oxidation of Cu surfaces under graphene has remained unclear and has limited the application of graphene as an oxidation barrier for various metals.
Although the LMNA gene defect responsible for this "premature aging syndrome" has been identified, biological mechanisms underlying the accelerated atherosclerosis are unknown.
To elucidate the mechanism underlying flagellin accelerated wound closure, we next investigated the effects of flagellin on EGFR signaling in cultured corneas (Fig. 9).
The mechanisms underlying this accelerated contraction are unknown.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com