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Among emerging evidences underlining the contribution of ET-1 axis to tumor progression is the finding that ET-1 can influence the accumulation of HIF-1α in different cell types, including melanoma, ovarian and breast cancer and lymphatic endothelial cells [16], [25] [28].
As in the case of MMP activity, all stimulated co-cultures with SFB showed a significantly higher caseinolytic activity than the respective monocultures, further underlining the contribution of the co-cultured SFB.
The labeled rostral hindbrain raphe domains identified in this way essentially correspond to our results, particularly in underlining the contribution of Is and r1 (not distinguished in this study) to the DR complex (B7, B6), but jointly also to the rostral MnR (part of B8) and SuL elements (part of B9).
Although the reduction of COMP mRNA was not influenced by co-culture with SFB, the loss of immunoreactive COMP protein from the cartilage matrix was strongly augmented by the SFB, further underlining the contribution of SFB to the disruption of the cartilage matrix homeostasis.
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This effect is called "bucket brigade", to underline the contribution of every single particle cycle to the total effect.
By the arguments they make, the study underlines the contribution of teaching process, centred on the student's activity, without diminishing the crucial role of the teacher.
The research took place with modern methods and it underlines the contribution of cellulose ethers to increasing the mortar physical and mechanical performance.
To underline, the contribution of scientists and physicists to the development of Nuclear Medicine has been not just major but disruptive and of fundamental importance.
Further, we underlined the contribution of proinflammatory cytokines such as CCL2 (MCP-1), IFN- γ and TNF to STZ-induced liver injury.
A conclusion underlines the contributions and shortcomings of current research and suggests possible directions.
The conclusion underlines the contributions and shortcomings of current research and suggests possible future directions.
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