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Here, by cross-species analysis of a large set of functional categories and all transcription factors and growth factors, we reveal conserved and divergent functional landscapes underlining fundamental and species-specific mechanisms that regulate ESC development.
But there is another underlining fundamental factor too that explains why we have run into this current socio-economic and political mess.
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Dubai's emergence certainly underlines fundamental changes in the global aerospace industry.
But they are giving him very few new troops on the ground, underlining the fundamental strains in the alliance.
In the week after European and African leaders met in Malta to discuss the impact of the migration and refugee crisis, it is worth underlining the fundamental importance of long-term development to alleviate such crises and make them less likely to recur.
Relatives of actin and tubulin are expressed in all phyla, underlining the fundamental importance of conserved cytoskeletal functions.
Interestingly, the estrogen receptor alpha and HER2/ERBB2, the major parameters characterizing 3 of the 5 different classes, are the goals for the most successful targeted therapies in breast cancer, underlining a fundamental role in biological control.
Underlining the fundamental importance of Bak in regulating platelet life span, there was no additive effect in Bak−/− BCL-2tg mice; platelet survival in these animals was indistinguishable from that seen in the Bak− / − cohort.
In fact, such distribution with the singularity of P−1 resembles the positional distribution of information content of kinase substrate specificity, underlining a fundamental link between the criticality of a given position for substrate recognition by upstream kinases and the disruptive potential of cancer somatic mutations hitting those positions.
Such central positions are generally devoid of drug targets, especially when they are part of the central proteome, which underline the fundamental role of these proteins whose activity should not be altered.
Their preliminary observations underlined the fundamental importance of open justice – "a hallmark and a safeguard of the rule of law … a fundamental principle … and a means of ensuring public confidence".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com